"Even a vaccine with moderate effectiveness could have a big impact," he said. The effects of the two interventions on gonorrhea were independent, and people who received both benefited from both, Molina told reporters at a CROI media briefing. DoxyPEP and the vaccine were safe and well tolerated, and no serious adverse events were reported. The likelihood of gonorrhea decreased by the same amount in the vaccine group. The risk for gonorrhea fell by 51% in the doxyPEP group, with greater protection against anal or urethral infection compared with throat infections. Over a median nine months of follow-up, the risk for chlamydia declined by 89%, while syphilis declined by 79%. Adherence was high, with the men reporting that they took doxycycline after sex about 80% of the time. The study was stopped early in September 2022 after a preliminary analysis showed that the intervention was effective. They were tested for chlamydia, gonorrhea and syphilis every three months.
Discharge gonorrhea symptoms in men plus#
Roughly half received doxycycline alone, half got doxycycline plus the vaccine, a quarter received the vaccine alone and a quarter got neither. They were randomly assigned to receive doxycycline PEP or the standard of care (STI testing and treatment after diagnosis) and separately randomized to receive two shots of the vaccine spaced two months apart or no vaccine.
Most were white men born in France, and the median age was 39 years.
Discharge gonorrhea symptoms in men trial#
The DoxyVAC study included 502 men who have sex with men in the ANRS Prevenir trial who were taking tenofovir disoproxil fumarate/emtricitabine (Truvada or generic equivalents) for HIV prevention and had an STI within the past year. But it also prevents infection with the related bacteria Neisseria gonorrhoeae, which causes gonorrhea. The meningococcal B vaccine (Bexsero, also known as 4CMenB) is approved for the prevention of Neisseria meningitidis, which causes bacterial meningitis. Among HIV-negative participants on pre-exposure prophylaxis (PrEP), the corresponding reductions were 88%, 55% and 87%, respectively.Īt CROI, Jean-Michel Molina, MD, of the University of Paris Cité, presented findings from another study that evaluated doxycycline PEP plus a vaccine to prevent gonorrhea. It found that those who took a 200 milligram dose of the antibiotic doxycycline within 72 hours after condomless sex saw a 74% reduction in the risk for chlamydia, a 57% decrease for gonorrhea and a 77% reduction for syphilis per quarter. Doxycycline post-exposure prophylaxis (doxyPEP) after sex is highly effective for preventing bacterial sexually transmitted infections (STIs) among gay men and transgender women-and adding a vaccine reduces the risk for gonorrhea-but this approach did not work well for cisgender women in Africa, according to research presented at the 30th Conference on Retroviruses and Opportunistic Infections (CROI).Īs reported at last summer's international AIDS Conference, the DoxyPEP study enrolled gay men and transgender women living with HIV in San Francisco and Seattle.
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